SECONDARY HYPERAMMONÆMIA: A POSSIBLE MECHANISM FOR VALPROATE ENCEPHALOPATHY
نویسندگان
چکیده
منابع مشابه
Mechanism for Valproate Encephalopathy
Sin,—Hyperglycinsemia, hyperglycinuria,l propionicaciduria2 and Reye’s syndrome3 have been reported in epileptic patients taking the anticonvulsant drug valproic acid (VPA). While investigating possible mechanisms of VPA toxicity we found increased plasma glycine and propionic acid concentrations in symptom-free patients taking VPA (table i). With informed consent, loading tests with 500 ...
متن کاملValproate-associated hyperammonemic encephalopathy.
The use of valproic acid (VPA) (also known as Depakote, Depakene, and others) frequently results in elevated plasma ammonia. In some people, hyperammonemia may be clinically significant, resulting in hyperammonemic encephalopathy, which may be severe. Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, despite normal doses and serum levels of VPA....
متن کاملNon-Hyperammonemic valproate encephalopathy
A 21-year-old male known case of primary hypothyroidism, Seizure disorder sequelae of an old trauma receiving sodium valproate, clobazam and phenobarbitone for control of Generalized tonic clonic seizures reported to neurology OPD with history of altered sensorium and gait unsteadiness for 1 week with history of hike in valproate dose 2 weeks before. On examination he was drowsy. Neurological e...
متن کامل[Valproate-induced hyperammonemic encephalopathy].
Encefalopatia hiperamonemica inducida por acido valproico.
متن کاملValproate-Induced Hyperammonemic Encephalopathy
Valproate is the best choice drug for a variety of medical conditions. As with any other drug, it has adverse effects, and it is important to emphasize the possibility of those adverse effects to prevent complications. We present the case history of a 44-year-old male with valproate-induced hyperammonemic encephalopathy, despite having normal liver function tests. This case includes a detailed ...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1980
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(80)91773-0